Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells
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چکیده
منابع مشابه
Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells.
When the TCR is formed in the thymus, fragments of DNA are excised from the T cell progenitor chromosome. These TCR rearrangement excision circles (TRECs) are stable, are not replicated in cell division and are therefore most frequent in naive T cells that have recently left the thymus. During life, the average TREC content of peripheral naive T cells decreases between one and two orders of mag...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2003
ISSN: 0022-5193
DOI: 10.1016/s0022-5193(03)00172-3